ParkinsonFranceV1, Main, Exploration, bibRecord, 002D94

Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease

Identifieur interne : 002D94 ( Main/Exploration ); précédent : 002D93; suivant : 002D95

Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease

Auteurs : Maria Martinez [France] ; Alexis Brice [France] ; Jenny R. Vaughan [Royaume-Uni] ; Alexander Zimprich [Allemagne] ; Monique M. B. Breteler [Pays-Bas] ; Giuseppe Meco [Italie] ; Alessandro Filla [Italie] ; Matthew J. Fatter [États-Unis] ; Christine Betard [France] ; Andrew Singleton [États-Unis] ; John Hardy [États-Unis] ; Giuseppe De Michele [Italie] ; Vincenzo Bonifati [Italie] ; Ben A. Oostra [Pays-Bas] ; Thomas Gasser [Allemagne] ; Nick W. Wood [Royaume-Uni] ; Alexandra Dürr [France]

Source :

American journal of medical genetics [ 0148-7299 ] ; 2005.

RBID : Pascal:05-0303643

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Apolipoprotéine E, Chromosome F19, Pathogénie, Déterminisme génétique, Liaison génétique, Carte génétique, Génétique, Homme.
Wicri :
- topic : Génétique, Homme.

English descriptors

KwdEn :
- Apolipoprotein E, Chromosome F19, Genetic determinism, Genetic linkage, Genetic mapping, Genetics, Human, Parkinson disease, Pathogenesis.

Abstract

Analysis of the apolipoprotein E genotype in sibpairs with Parkinson's disease showed the E4 allele was over represented in those who shared the adjacent chromosome 19 markers. This suggests that apolipoprotein E4 is responsible for the linkage peak in this region and that it is a modest risk factor for Parkinson's disease.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000C72
to stream PascalFrancis, to step Curation: 000762
to stream PascalFrancis, to step Checkpoint: 000B54
to stream Main, to step Merge: 003177
to stream Main, to step Curation: 002D94

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease</title>
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<author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A." last="Oostra">Ben A. Oostra</name>
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<s2>Rotterdam</s2>
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<sZ>14 aut.</sZ>
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<author><name sortKey="Wood, Nick W" sort="Wood, Nick W" uniqKey="Wood N" first="Nick W." last="Wood">Nick W. Wood</name>
<affiliation wicri:level="4"><inist:fA14 i1="12"><s1>Department of Molecular Neuroscience, Institute of Neurology, University College London</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author><name sortKey="Durr, Alexandra" sort="Durr, Alexandra" uniqKey="Durr A" first="Alexandra" last="Dürr">Alexandra Dürr</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>INSERM U289 and Département de Ge'ne'tique, Cytoge'ne'tique et Embryologie, Hôpital La Pitité-Salpêtrière</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">American journal of medical genetics</title>
<title level="j" type="abbreviated">Am. j. med. genet.</title>
<idno type="ISSN">0148-7299</idno>
<imprint><date when="2005">2005</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">American journal of medical genetics</title>
<title level="j" type="abbreviated">Am. j. med. genet.</title>
<idno type="ISSN">0148-7299</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Apolipoprotein E</term>
<term>Chromosome F19</term>
<term>Genetic determinism</term>
<term>Genetic linkage</term>
<term>Genetic mapping</term>
<term>Genetics</term>
<term>Human</term>
<term>Parkinson disease</term>
<term>Pathogenesis</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Apolipoprotéine E</term>
<term>Chromosome F19</term>
<term>Pathogénie</term>
<term>Déterminisme génétique</term>
<term>Liaison génétique</term>
<term>Carte génétique</term>
<term>Génétique</term>
<term>Homme</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Génétique</term>
<term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Analysis of the apolipoprotein E genotype in sibpairs with Parkinson's disease showed the E4 allele was over represented in those who shared the adjacent chromosome 19 markers. This suggests that apolipoprotein E4 is responsible for the linkage peak in this region and that it is a modest risk factor for Parkinson's disease.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>France</li>
<li>Italie</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Bade-Wurtemberg</li>
<li>District de Tübingen</li>
<li>Floride</li>
<li>Grand Londres</li>
<li>Hollande-Méridionale</li>
<li>Latium</li>
<li>Maryland</li>
<li>Île-de-France</li>
</region>
<settlement><li>Londres</li>
<li>Paris</li>
<li>Rome</li>
<li>Rotterdam</li>
<li>Tübingen</li>
<li>Évry (Essonne)</li>
</settlement>
<orgName><li>University College de Londres</li>
</orgName>
</list>
<tree><country name="France"><region name="Île-de-France"><name sortKey="Martinez, Maria" sort="Martinez, Maria" uniqKey="Martinez M" first="Maria" last="Martinez">Maria Martinez</name>
</region>
<name sortKey="Betard, Christine" sort="Betard, Christine" uniqKey="Betard C" first="Christine" last="Betard">Christine Betard</name>
<name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name>
<name sortKey="Durr, Alexandra" sort="Durr, Alexandra" uniqKey="Durr A" first="Alexandra" last="Dürr">Alexandra Dürr</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Vaughan, Jenny R" sort="Vaughan, Jenny R" uniqKey="Vaughan J" first="Jenny R." last="Vaughan">Jenny R. Vaughan</name>
</region>
<name sortKey="Wood, Nick W" sort="Wood, Nick W" uniqKey="Wood N" first="Nick W." last="Wood">Nick W. Wood</name>
</country>
<country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Zimprich, Alexander" sort="Zimprich, Alexander" uniqKey="Zimprich A" first="Alexander" last="Zimprich">Alexander Zimprich</name>
</region>
<name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name>
</country>
<country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Breteler, Monique M B" sort="Breteler, Monique M B" uniqKey="Breteler M" first="Monique M. B." last="Breteler">Monique M. B. Breteler</name>
</region>
<name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A." last="Oostra">Ben A. Oostra</name>
</country>
<country name="Italie"><region name="Latium"><name sortKey="Meco, Giuseppe" sort="Meco, Giuseppe" uniqKey="Meco G" first="Giuseppe" last="Meco">Giuseppe Meco</name>
</region>
<name sortKey="Bonifati, Vincenzo" sort="Bonifati, Vincenzo" uniqKey="Bonifati V" first="Vincenzo" last="Bonifati">Vincenzo Bonifati</name>
<name sortKey="De Michele, Giuseppe" sort="De Michele, Giuseppe" uniqKey="De Michele G" first="Giuseppe" last="De Michele">Giuseppe De Michele</name>
<name sortKey="Filla, Alessandro" sort="Filla, Alessandro" uniqKey="Filla A" first="Alessandro" last="Filla">Alessandro Filla</name>
</country>
<country name="États-Unis"><region name="Floride"><name sortKey="Fatter, Matthew J" sort="Fatter, Matthew J" uniqKey="Fatter M" first="Matthew J." last="Fatter">Matthew J. Fatter</name>
</region>
<name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name>
<name sortKey="Singleton, Andrew" sort="Singleton, Andrew" uniqKey="Singleton A" first="Andrew" last="Singleton">Andrew Singleton</name>
</country>
</tree>
</affiliations>
</record>

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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease

Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease

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